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. 2021 May 1;49(W1):W409–W416. doi: 10.1093/nar/gkab297

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Use case 2—aniridia genes and miRNAs. (A) Interactions between downregulated miRNAs (blue nodes) and upregulated genes (green nodes) with a minimum of three shared targets. (B) The enlarged core part of the interaction network shown in (A). (C) The opposite case upregulated miRNAs and downregulated genes. (D) The enlarged central part of the interaction graph shown in (C). (E) Top 10 significant miEAA pathways for the network in panel (C). Following the category name, the raw and adjusted P-value are provided, followed by the expected number of miRNAs by chance and the actual observed number.