Skip to main content
. 2021 Feb 4;130(4):1122–1132. doi: 10.1152/japplphysiol.00817.2020

Figure 1.

Figure 1.

Olfr78 null mice exhibit impaired breathing responses to hypobaric hypoxia (HH). A and B: representative tracings of breathing in unanesthetized wild type (WT) (A) and Olfr78 null (Olfr78−/−) mice (B) while breathing room air (21% O2) or hypoxia (12% O2) before and after HH (0.4 atmospheres) for 18 h. Tracings represent breathing in same mice before and after HH. C–F: individual data points of respiratory rate (RR; breaths/min; C), tidal volume (VT, µL/g of body weight; D), and minute ventilation (VE, mL/g · min; E) normalized to body weight and oxygen consumption (VE/VO2; F). G–J: individual data points show hypoxic ventilatory responses (HVR) to 12% O2 breathing in WT and Olfr78−/− mice before and after HH. HVR was determined in the same mice before and after HH. Respiratory rate (breaths/min; G); tidal volume (VT, µL/g of body weight; H), and minute ventilation (VE, mL/g · min; I) VE normalized to body weight and oxygen consumption (VE/VO2; J). Numbers in parenthesis represent the number of mice. **P < 0.01; n.s., not significant, P > 0.05; compared to WT, two-way ANOVA with repeated measures followed by Tukey’s test.