FIG 5.

Comparative analysis of HIRAN domains. The HIRAN domains of HipL and HipN have sequence motifs required for DNA binding. (A) Schematic overview of the HIRAN domain found in human helicase-like transcription factor (HLTF) showing the relative positions and sequences involved in ssDNA and dsDNA binding (72). (B) Structure of the human HLTF HIRAN domain with the four regions necessary for DNA binding shown as sticks (PDB accession no. 4XZF) (72). (C) Overview of sequence motifs present (+) or absent (−) in homologues of HipL and HipN.