TABLE 1.

Overview of the clades of the Hip Tree consisting of 1,239 kinases^a

Clade	No. of kinase genes	TA gene organizationb	Experimentally analyzed TA modules	Cellular target(s) of toxin	GenBank IDc	Reference(s)
I	712	hipBA	hipBA of E. coli K-12	GltX	NP_416024.1 (440)	47, 51, 52, 57, 58
			hipBA1 of C. crescentus	Unknown or GltX and LysS	ACL93947.1 (423)
			hipBA2 of C. crescentus	LysS or GltX, LysS and TrpSe	ACL96286.1 (444)
			hipBA3 of C. crescentus	Unknowne	WP_010920611.1 (435)d
			hipBA of S. oneidensis MR-1	Unknown	AAN53784.1 (433)
II	73	hipBA	None
III	48	hipBA	hipBST of E. coli O127	TrpS	WP_015879003.1 (342)	59
			H. influenzae KW20	TrpS	NP_438824.1 (343)
			T. auensis DSM9187	TrpS	CAS11333.1 (335)
IV	14	hipBA	None
V	9	hipBA	None
VI	36	hipBA	None
VII	132	hipAB and hipAB	None
VIII	21	hipBA	None
IX	12	hipEB	None
X	101	hipH/yjjJ	hipH/yjjJ		P39410.1 (443)	60
XI	81	hipRF, hipRG, hipMP, hipL, hipIN, and hipJS	None

^aData compiled from Table S1 in the supplemental material.

^bGene organization refers to information retrieved from Table S1 and visualized schematically in Fig. 2B.

^cGenBank identifiers (IDs) or accession numbers of the kinases are from Table S1 and their position in amino acids in the Hip Tree visualized in Fig. S2A and S2B in the supplemental material.

^dhipBA₃ of C. crescentus previously had the accession number NP_421566.1 and was used in Table S1.

^eThe substrate of HipA₁ is either unknown (58) or GltX plus LysS (57), while the substrate of HipA₂ is either TrpS (58) or GltX, LysS plus TrpS (57).