FIG 5.

Trajectories and stages in the experimental evolution of CIP resistance in E. coli (top), A. baumannii (middle), and P. aeruginosa (bottom). Major driver mutations are shown in color-coded boxes, with missense mutations in targets (green and blue) and disruptive mutations in efflux regulators (yellow and brown). Additional potentially relevant mutations detected in populations but not in isolated clones are shown on a gray background.