TABLE 1.
Minimum inhibitory and bactericidal concentrations determined for the wild-type K. pneumoniae MGH78578 and the K. pneumoniae MGH78578 ΔsoxS isogenic mutant
| Antimicrobial compound | MICs and MBCsa (μg/ml) |
|||
|---|---|---|---|---|
|
K. pneumoniae MGH78578 |
K. pneumoniae MGH78578 ΔsoxS |
|||
| MIC | MBC | MIC | MBC | |
| Colistin | 0.25 (S) | 0.5 | 0.125 (S) | 0.125 |
| Kanamycin | >512 (R) | >512 | >512 (R) | >512 |
| Gentamicin | 128 (R) | 128 | 64 (R) | 64 |
| Cefotaxime | 32 (R) | 64 | 1 (S) | 1 |
| Tetracycline | 128 (−) | 128 | 2 (−) | 16 |
a
Results indicate the median value from 3 independent assays. MIC values shown are interpreted according to EUCAST guidelines. (S), susceptible; (R), resistant; (−) not available.