Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of the putative role of RgpA in the regulation of LPS signaling in gingival keratinocytes. RgpA secreted by P. gingivalis penetrates into the cytoplasm, degrades MCPIP-1, and sensitizes epithelial cells to endotoxins and to both commensal and pathogenic species. Additionally, the released cytokines activate a proinflammatory signaling cascade via the autocrine pathway, leading to exacerbation of the local inflammatory reaction.
