FIG 2.

Effect of MDEs on the cell wall of C. albicans and its binding potential with GtfB. Dose-dependent degradation of the cell wall mannans in the supernatant (A) and a corresponding decrease in the pellet of C. albicans (B), and the amount of glucans formed on each C. albicans with or without MDE treatment (C). The amount of mannans on MDE-treated C. albicans in supernatant increased while it decreased from the microbial pellet. In the presence of sucrose, smaller amounts of bound GtfB in MDE-treated C. albicans led to reduced glucan formation. Panel C statistics employed one-way ANOVA with P < 0.0001 post hoc; ***, P < 0.001; **** P < 0.0001 against vehicle control using Dunnett’s method (n ≥ 3).