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. 2021 May 11;12(3):e00605-21. doi: 10.1128/mBio.00605-21

FIG 10.

FIG 10

TrpA 3D predicted structures of Ct clinical G_UK750369 and reference G_UW57 strains (a to i). (a) TrpA structure of mutant strain G_UK750369 (cyan) superimposed on the template 5tch (magenta), with α-Loop 6 (α-L6) of the α-subunit in blue and malonate ion (MLI) in orange. The aa substitution in relation to G_UW57 at Y177 and K206 is in yellow. (b and c) Structural changes and location of the α-L6 and catalytic and subunit interaction regions of the mutant G_UK750369 are shown. (d) TrpA structure of G_UW57 (green) superimposed on the template 5tch (magenta) with annotations as per panels a, b, and c. (e and f) Structural changes in the α-L6 and catalytic and subunit interaction regions of the reference G_UW57. (g) TrpA predicted structures of G_UK750369 superimposed on G_UW57 (g) with structural changes noted in relation to α-L6 based on C177Y aa substitution (h) and catalytic and subunit interaction region based on R206K (i).