Table 3.
Comparison of main clinical features and investigation results in RFC1-positive and -negative patients
| RFC1+ | RFC1− | P-value | |
|---|---|---|---|
| Mean age at onset | 56 (30–75) | 58 (12–85) | 0.17 |
| Male sex | 25/43 (58%) | 38/60 (63%) | 0.59 |
| Cough | 26/37 (70%) | 5/54 (9%) | 0.00 |
| Unsteadiness | 30/43 (70%) | 29/55 (53%) | 0.08 |
| History of falls | 15/43 (35%) | 6/56 (10%) | 0.00 |
| Chronic progression | 35/43 (81%) | 29/58 (50%) | 0.00 |
| Need for walking support | 16/43 (37%) | 6/58 (10%) | 0.00 |
| Sensory symptoms (non-length-dependent distribution) | 9/29 (31%) | 13/47 (28%) | 0.95 |
| Impaired vibratory sensation at knee or above | 27/43 (63%) | 13/57 (22%) | 0.00 |
| Non length-dependent pattern at NCS | 30/43 (70%) | 15/55 (27%) | 0.00 |
| Absent SAPs at UL | 22/35 (63%) | 10/40 (25%) | 0.00 |
| Cerebellar symptoms | 10/43 (23%) | 4/56 (7%) | 0.02 |
| Cerebellar signs | 20/40 (50%) | 12/58 (21%) | 0.00 |
| Vestibular symptoms | 4/43 (9%) | 1/58 (1%) | 0.09 |
| Vestibular signs | 12/26 (46%) | 2/37 (5%) | 0.00 |
Values are provided mean (range) or n (%). Values in bold indicate significance. NCS = nerve conduction studies; SAPs = sensory action potentials; UL= upper limbs.