TABLE 2.
Multivariate analysis of the association between rs646564 in PFKFB3 and risk of IPAa
| Genetic or clinical variable | Adjusted HRb (95% CI) (n = 439) | P value |
|---|---|---|
| Donor TT at rs646564 | 2.72 (1.46–5.06) | 0.0017 |
| aGVHD III-IV | 3.84 (1.46–10.1) | 0.0062 |
a
Multivariate analyses were based on the subdistribution regression model of Fine and Gray. aGVHD, acute graft-versus-host-disease.
b
Hazard ratios were adjusted for patient age and gender, hematological malignancy, type of transplantation, conditioning regimen, development of acute GVHD (aGVHD) grade III-IV and antifungal prophylaxis. Only the variables remaining significant after adjustment are shown. HR, hazard ratio; CI, confidence interval.