FIG 4.

Differences in gut mycobiota communities in stool samples collected at 1 year of age among infants in the CHILD Cohort Study who developed inhalant atopy at age 5 years or remained healthy. (A) Fungal alpha diversity (top: Shannon; bottom: Chao1). (B) Total fungal load shown as ITS-2 copy number on a log scale. (C) Principal coordinate plot of samples based on Bray-Curtis dissimilarity of variance stabilized ASV count data. (D) Log fold change of fungal ASVs identified to show significant (false-discovery rate < 0.05) differences in relative abundance according to inhalant atopy status at age 5 years determined using DESeq2. Error bars indicate standard errors, and taxonomic annotations of ASVs are shown on the y axis. Positive numbers indicate that ASV was increased in abundance in cases relative to controls. Dots and lines represent the sample mean and range, respectively, in all Tufte plots.