Table 1.

Baseline characteristics of the whole cohort, patients with intact survival (ICU discharge FSS same as admission or better), and worse functional status (FSS on ICU discharge higher than baseline FSS)

Baseline characteristics	All surviving CKRT patients n = 45	Intact survival n = 14	Higher FSS at ICU discharge n = 31	p-value
Female	19 (42%)	6 (32%)	18 (69%)	0.954
Age, years	4 (0.8–11)	4.5 (0.8–12)	4 (0.8–10)	0.720
Total number of comorbidities	2 (1, 4)	2.5 (1, 5)	2 (1, 4)	0.412
Genetic comorbidity	7 (16%)	5 (71%)	2 (29%)	0.023`
Tracheostomy on admission	1 (2%)	1 (100%)	0	0.331`
G-tube dependent on admission	6 (13%)	4 (67%)	2 (33%)	0.065`
Baseline FSS	6 (6, 9)	8.5 (6, 17)	6 (6, 6)	0.007
PELOD on ICU admission	12 (10, 31)	10.5 (0, 31)	22 (10, 31)	0.247
Cardiopulmonary Resuscitation	4 (9%)	1 (25%)	3 (75%)	1.000`
New seizure	4 (9%)	2 (50%)	2 (50%)	0.578`
Mechanical ventilation	40 (89%)	12 (30%)	28 (70%)	0.639`
Length of invasive mechanical ventilation, days	8 (3, 32)	5 (1, 8)	11 (5, 34)	0.056
≥ 10 days		3 (14%)	19 (86%)	0.013
Highest OI	8.5 (3, 19.6)	5 (2.4, 23.4)	9.3 (3, 19.6)	0.515
Days on sedation	8 (2, 25)	3.5 (1, 8)	10 (0, 34)	0.127
≥ 9 days		3 (14%)	18 (86%)	0.023
Days on neuromuscular blockade	1 (0, 5)	0 (0, 3)	2 (0, 7)	0.097
≥ 1 day		5 (19%)	22 (81%)	0.025
Days on parenteral nutrition	8 (0, 17)	5 (0, 10)	8 (3, 25)	0.192
Days on CKRT	9 (3, 18)	5 (2, 8)	12 (6, 27)	0.020
Repeat CKRT	3 (7%)	0	3 (100%)	0.541`
PELOD at CKRT start	31 (12, 32)	26.5 (10, 40)	32 (12, 32)	0.630
% fluid overload at CKRT start	34.5 (11, 70)	26.5 (2.6, 49)	42.5 (18, 74)	0.124
Hemodialysis	26 (58%)	8 (31%)	18 (69%)	0.003

CKRT, continuous kidney replacement therapy; FSS, Functional Status Scale; GI, Gastrointestinal; ICU, intensive care unit; OI, oxygenation index; OR, operating room