Figure 1. K284 inhibits PA-induced AD. (A) PA solution was applied topically to the dorsal skin of mice in each group 3 times a week for 4 wk. K284 was topically administrated to the dorsal skin 2 h before PA solution application with indicated doses. (B) The photographs are representative of each group of mice. Bar graphs represent clinical scores, epidermal thickness and the number of mast cells. Scale bar=100 μm. (C) The morphologic, histologic and the number of mast cell changes in mice. (D) Serum IgE concentration was measured by ELISA (n=5). (E) Changes of skin draining lymph node weight in each group (n=5).

^#Control vs. PA and ^*PA vs. PA+K284. ^*p<0.05, ^**p<0.01 and ^###,***p<0.001.