Table 2.

Hazards ratio for risk of different outcomes in multivariate adjusted analysis with anticoagulant use as time-dependent covariate

	HR	95% CI	p Value
Stroke
HFpEF vs. No HF	1.09	1.03–1.16	0.005
HFrEF vs. No HF	1.08	1.03–1.14	0.004
HFpEF vs. HFrEF	1.01	0.93–1.08	0.88
HF admissions
HFpEF vs. No HF	1.65	1.61–1.70	<0.0001
HFrEF vs. No HF	1.86	1.82–1.90	<0.0001
HFpEF vs. HFrEF	0.89	0.86–0.92	<0.0001
Myocardial infarction
HFpEF vs. No HF	1.13	1.06–1.21	0.0002
HFrEF vs. No HF	1.2	1.14–1.26	<0.0001
HFpEF vs. HFrEF	0.94	0.87–1.02	0.12
Gastrointestinal bleeding
HFpEF vs. No HF	1.01	0.96–1.06	0.85
HFrEF vs. No HF	0.98	0.94–1.03	0.38
HFpEF vs. HFrEF	1.03	0.96–1.09	0.44
Intra-cranial hemorrhage
HFpEF vs. No HF	0.95	0.81–1.10	0.5
HFrEF vs. No HF	0.81	0.71–0.93	0.003
HFpEF vs. HFrEF	1.16	0.95–1.42	0.14
Any hemorrhage
HFpEF vs. No HF	1.01	0.97–1.06	0.2
HFrEF vs. No HF	0.97	0.94–1.02	0.2
HFpEF vs. HFrEF	1.04	0.98–1.10	0.15
All-cause mortality
HFpEF vs. No HF	0.99	0.96–1.01	0.3
HFrEF vs. No HF	1.10	1.08–1.13	<0.001
HFpEF vs. HFrEF	0.90	0.87–0.92	<0.001