Table 3.
CircRNAs causing VSMC disorder in AAAs.
| circRNA | Cell type | Inducing factor | Expression | Pathway | Function | Ref |
|---|---|---|---|---|---|---|
| circ_0010283 | VSMCs | ox-LDL | Up | miR-370-3p/HMGB1 | Promoted VSMC viability and migration, and proliferating cell nuclear antigen | 125 |
| HVSMCs | ox-LDL | Up | miR-133a-3p/PAPPA | Promoted VSMC proliferation, migration and invasion | 126 | |
| circCHFR | VSMCs | ox-LDL | Up | miR-370/FOXO1/Cyclin D1 | Promoted proliferation and migration ability of VSMCs | 127 |
| VSMCs | ox-LDL | Up | miR-214-3p/Wnt3/β-catenin | Promoted cell growth, migration, and inflammation | 128 | |
| circ_0029589 | VSMCs | ox-LDL | Up | miR-424-5p/IGF2 | Promoted proliferation, migration, and invasion | 129 |
| VSMCs | ox-LDL | Up | miR-214-3p and STIM1 | Promoted proliferation, migration, and invasion | 130 | |
| circNRG-1 | MASMCs | Ang II | Down | miR-193b-5p/NRG-1 | Promoted apoptosis | 131 |
| circWDR77 | VSMCs | HG | Up | miR-124/FGF-2 | Promoted migration and proliferation | |
| circ_0077930 | HUVEC-Exos>VSMCs | HG | — | miR-622-Kras | Induce cellular senescence in VSMCs | 132 |
| circ_0044073 | HUVEC | LPS | Down | miR-107/JAK/STAT | Promoted the proliferation and invasion | 133 |
| HUVSMCs | Up | |||||
| circ-Sirt1 | VSMCs | TNF-α | Down | miR-132/212/SIRT1 | Inhibited inflammation | 134 |
| circDHCR24 | HA-VSMC | PDGF-BB | Up | miR-149-5p/MMP9 | Promoted proliferation, migration, and phenotypic switch | 135 |
| circ-SATB2 | Proliferative VSMCs | N/A | Up | miR-939/STM1 | Promoted migration, proliferation; inhibited apoptosis | 136 |
| circ-RUSC2 | Proliferative VSMCs | N/A | Up | miR-661/SYK | Promoted migration, proliferation; inhibited apoptosis | 137 |
| circACTA2 | HASMCs | N/A | Up | NRG-1/circACTA2/miR-548f-5p | Promoted contraction |