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| Name | Target structure | Year of Approval | Year of designation |
|---|---|---|---|
| 5-aminolevulinic acid | intraoperative optical imaging agent | 2017 | 2013 |
| Bevacizumab | Inhibition of angiogenesis (antibody against VEGF) | 2009 | 2006 |
| Polifeprosan 20 with carmustine | Implant to deliver the approved drug carmustine | 2003 | 1989 |
| Lomustine | Alkylating compound | 1976 | unknown |
| Temozolomide | Alkylating compound | 2006 | 1998 |
