Table 2.
Univariate analysis of clinicopathological characteristics correlated with con-CLNM in uni-PTC.
| Characteristics | Total (n = 250) (%) | Con-CLNM (+) (n = 75) (%) | Con-CLNM (−) (n = 175) (%) | p |
|---|---|---|---|---|
| Age (yrs) | 39.67 ± 11.36 | 35.44 ± 11.38 | 41.49 ± 10.89 | <0.001 b |
| Age ˂55 | 225 (90.0) | 71 (94.7) | 154 (88.0) | 0.107a |
| Male sex | 49 (19.6) | 26 (34.7) | 23 (13.1) | <0.001 a |
| TSH level | 2.77 ± 4.21 | 2.44 ± 2.07 | 2.91 ± 4.84 | 0.420b |
| Hashimoto's thyroiditis | 120 (48.0) | 25 (33.3) | 95 (54.3) | 0.002 a |
| BRAFV600E mutation | 179 (71.6) | 54 (72.0) | 125 (71.4) | 0.927a |
| Sonographic characteristics | ||||
| Solid composition | 240 (96.0) | 69 (92.0) | 171 (97.7) | 0.078c |
| Hypoechogenic | 220 (88.0) | 61 (81.3) | 159 (90.9) | 0.034 a |
| Irregular shape | 182 (72.8) | 58 (77.3) | 124 (70.9) | 0.292a |
| Poorly marginal | 167 (66.8) | 46 (61.3) | 121 (69.1) | 0.230a |
| Oval | 50 (20.0) | 12 (16.0) | 38 (21.7) | 0.301a |
| Microcalcifications | 212 (84.8) | 71 (94.7) | 141 (80.6) | 0.004 a |
| Vascularity | ||||
| Absent | 58 (23.2) | 17 (22.7) | 41 (23.4) | 0.381a |
| Few | 120 (48.0) | 32 (42.7) | 88 (50.3) | |
| Abundant | 72 (28.8) | 26 (34.6) | 46 (26.3) | |
| Pathological characteristics | ||||
| Multifocality | 21 (8.4) | 6 (8.0) | 15 (8.6) | 0.881a |
| Location of primary tumor | ||||
| Superior lobe | 54 (21.6) | 19 (25.3) | 35 (20.0) | 0.539a |
| Middle lobe | 141 (56.4) | 42 (56.0) | 99 (56.6) | |
| Inferior lobe | 55 (22.0) | 14 (18.7) | 41 (23.4) | |
| Capsular invasion | 83 (33.2) | 41 (54.7) | 42 (24.0) | <0.001 a |
| ETE | 58 (23.2) | 28 (37.3) | 30 (17.1) | <0.001 a |
| Tumor size (mm) | 15.95 ± 10.25 | 19.30 ± 10.83 | 14.51 ± 9.68 | <0.001 b |
| Diameter >10 | 155 (62.0) | 59 (78.7) | 96 (54.9) | <0.001 a |
| Pathologically confirmed ipsi-CLNM | ||||
| Present | 154 (61.6) | 72 (96.0) | 82 (46.9) | <0.001 a |
| Ipsilateral central LN | ||||
| Metastasis number | 2.54 ± 3.27 | 4.69 ± 3.88 | 1.61 ± 2.46 | <0.001 b |
| Harvested number | 7.62 ± 4.75 | 7.43 ± 4.64 | 7.70 ± 4.81 | 0.674b |
| Metastasis ratio | 0.34 ± 0.35 | 0.64 ± 0.30 | 0.21 ± 0.29 | <0.001 b |
| Pathologically confirmed ipsi-LLNM | ||||
| Present | 86 (34.4) | 48 (64.0) | 38 (21.7) | <0.001 a |
Note: Variables with statistical significance are shown in bold. aChi-square test, bStudent's t test, and cFisher's exact test were adopted. Abbreviations: con-CLNM, contralateral central lymph node metastasis; ETE, extrathyroid extension; ipsi-CLNM, ipsilateral central lymph node metastasis; oval, taller than wide; TSH, thyrotropin; uni-PTC, unilateral papillary thyroid carcinoma.