TABLE 3.

Regression Analysis of Cumulative Net Fluid Balance

Regression Variable	Effect Estimate (mL)	se (95% CIs)	p
Unadjusted analysis
Study observation day	+297	32 (+234 to +360)	<0.001
Clinician-recognized ARDS	+525	536 (–525 to +1,574)	0.33
Adjusted analysis
Study observation day	+297	32 (+234 to +360)	<0.001
Presence of shock at admission	+2,133	559 (+1,053 to +3,229)	<0.001
Oxygenation impairmenta	+424	359 (–279 to +1,128)	0.24
Presence of congestive heart failure or chronic kidney disease	–1,010	652 (–2,289 to +268)	0.12
Clinician-recognized ARDS	–781	543 (–1,846 to +283)	0.15

ARDS = acute respiratory distress syndrome.

^aOxygenation impairment was categorized into four ordinal groups using the lowest Pao₂:Fio₂ and/or Spo₂:Fio₂ ratio during the first 4 ICU days: severe ARDS (Pao₂:Fio₂ ≤ 100), moderate ARDS (Pao₂:Fio₂ ≥ 101 and ≤ 200), mild ARDS (Pao₂:Fio₂ ≥ 201 and ≤ 300), or ARDS met by Spo₂:Fio₂ criteria only (lowest Pao₂:Fio₂ > 300, but lowest Spo₂:Fio₂ ≤ 315 while Spo₂ > 96%) (29).