Table 3.
Biochemical variables according to albuminuria severity (reflected by albumin/creatinine ratio) (n = 184)
| Variable | Mild (ACR1) (n = 80) (0–300 mg/g) | Moderate (ACR2) (n = 83) (300–3000 mg/g) | Severe (ACR3) (n = 21) (>3000 mg/g) | p value |
|---|---|---|---|---|
| Albumin (mg/g creatinine) | 36.5 (10.0–140.0), n = 80 | 1210.0 (63.0–2041.0), n = 83 | 5415.0 (3816.0–8163.5), n = 21 | <0.0001 |
| Serum albumin (mg/dl) | 4.3 (4.1–4.5), n = 76 | 4.2 (3.9–4.4), n = 80 | 3.4 (3.0–3.9), n = 19 | <0.0001 |
| eGFR (ml/min/1.73 m2)) | 26.06 (18.4–39.7), n = 79 | 25.8 (16.08–50.50), n = 83 | 16.94 (13.02–47.30), n = 21 | n.s. |
| TSH (µU/ml) | 1.6 (0.8–2.3), n = 75 | 1.4 (1.0–2.0), n = 78 | 1.8 (1.1–2.6), n = 20 | n.s. |
| T4 (nmol/l) | 88 (75–100), n = 75 | 97 (82–104), n = 78 | 79 (73–90), n = 20 | <0.05 |
| fT4 (pmol/l) | 16.2 (14.7–17.7), n = 78 | 16.8 (15.0–18.8), n = 81 | 16.9 (15.5–19.5), n = 21 | n.s. |
| T3 (nmol/l) | 1.8 (1.5–2.0), n = 73 | 1.8 (1.6–2.1), n = 79 | 1.8 (1.5–2.0), n = 20 | n.s. |
| fT3 (pmol/l) | 4.6 (4.0–4.9), n = 80 | 4.4 (4.1–4.9), n = 79 | 4.5 (4.3–5.0), n = 21 | n.s. |
| rT3 (nmol/l) | 0.36 (0.31–0.40), n = 75 | 0.32 (0.25–0.38), n = 78 | 0.28 (0.22–0.36), n = 20 | <0.001 |
| rT3/T3 | 0.21 (0.16–0.27), n = 73 | 0.16 (0.14–0.22), n = 79 | 0.16 (0.12–0.20), n = 20 | <0.001 |
| rT3/T4 | 0.0040 (0.0035–0.0049), n = 75 | 0.0034 (0.0028–0.0040), n = 78 | 0.0035 (0.0026–0.0039), n = 20 | <0.0001 |
| TBG (mg/l) | 18 (15–21), n = 78 | 18 (16–21), n = 79 | 17 (15–20), n = 20 | n.s. |
Differences between subgroups were calculated via Kruskal–Wallis tests. Values other than p values are given as median (25th–75th percentiles)
ACR albumin/creatinine ration, eGFR estimated glomerular filtration rate, fT3 free trioodothyronine, fT4 free thyroxine, n.s. not significant, rT3 reverse triiodothyronine, T3 triiodothyronine, T4 thyroxine, TBG thyroxine-binding globulin, TSH thyroid-stimulating hormone