. 2021 Mar 13;48(9):2951–2959. doi: 10.1007/s00259-021-05296-1

Table 2.

Sensitivity, specificity and accuracy of both readers of each imaging modality in pessimistic and optimistic analysis at the patient level

Imaging modality	Reader	Pessimistic analysis			Optimistic analysis
Imaging modality	Reader	Sensitivity (95%CI)	Specificity (95%CI)	Accuracy (95%CI)	Sensitivity (95%CI)	Specificity (95%CI)	Accuracy (95%CI)
CT	1	0.39 (0.24–0.56) ^a,b	0.94 (0.83–0.98)	0.72 (0.61–0.80) ^a,b	0.16 (0.07–0.32) ^a,b	1.00 (0.93–1.00)	0.67 (0.56–0.76) ^a,b
CT	2	0.32 (0.19–0.50) ^a,b	0.94 (0.83–0.98)	0.70 (0.59–0.79) ^a,b	0.26 (0.14–0.43) ^a,b	0.98 (0.89–0.99)	0.70 (0.59–0.79) ^a,b
WBMRI with DWI	1	0.40 (0.25–0.58) ^a,b	0.96 (0.86–0.99)	0.74 (0.63–0.83) ^a,b	0.37 (0.22–0.55) ^a,b	0.98 (0.89–1.00)	0.74 (0.63–0.83) ^a,b
WBMRI with DWI	2	0.50 (0.33–0.67) ^a,b	0.91 (0.80–0.97)	0.75 (0.65–0.84) ^a,b	0.37 (0.22–0.55) ^a,b	0.98 (0.89–1.00)	0.74 (0.63–0.83) ^a,b
¹⁸F-PSMA-1007 PET/CT	1	0.84 (0.67–0.93)	0.96 (0.86–0.99)	0.91 (0.83–0.96)	0.77 (0.60–0.89)	0.98 (0.89–1.00)	0.90 (0.81–0.95)
¹⁸F-PSMA-1007 PET/CT	2	0.90 (0.75–0.97)	0.94 (0.83–0.98)	0.93 (0.85–0.96)	0.87 (0.71–0.95)	0.96 (0.86–0.99)	0.92 (0.84–0.96)

CT computed tomography, WBMRI whole-body magnetic resonance imaging, DWI diffusion-weighted imaging, ¹⁸F-PSMA-1007 PET/CT prostate-specific membrane antigen positron emission tomography-CT, CI confidence interval

^aStatistically significant difference (p < 0.05) compared to ¹⁸F-PSMA-1007 PET/CT reader 1

^bStatistically significant difference (p < 0.05) compared to ¹⁸F-PSMA-1007 PET/CT reader 2