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. 2021 Mar 26;476(8):2963–2973. doi: 10.1007/s11010-021-04128-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — TβRIII levels in human glioblastoma in vivo. a TβRIII was detected immunohistochemically and quantified using the H-score in a TMA comprising 13 normal brain tissue samples obtained from epilepsy surgery and in tissue sections of 57 newly diagnosed and nine recurrent glioblastoma patients. Non-endothelial and endothelial cells, which were identified topographically aligning tumor vessels, were analyzed and scored separately; mean values are marked by the line, *indicates significance p < 0.001. b Representative photomicrographs of tissue sections from a analyzed for expression of TβRIII (red) and the endothelial marker vWF (green) by immunofluorescence. Scale bar: 50 µm. DNA was stained with 4′,6-diamidino-2-phenylindole (DAPI). c TβRIII expression was determined in CD31⁺ versus CD31⁻ cell fractions of freshly dissociated glioblastoma tissues by RT-PCR. d Supernatants from CD31⁺ (endothelial) cells of three freshly dissected glioblastomas were assessed by ELISA for levels of shed TβRIII. Data were normalized to protein concentration of supernatants. (Color figure online)