. Author manuscript; available in PMC: 2022 Aug 1.

Published in final edited form as: Mol Cell Endocrinol. 2021 May 27;533:111335. doi: 10.1016/j.mce.2021.111335

Table 1.

Serum and hepatic oxidative stress markers in WT and Scly KO mice fed a high-fat, Se-supplemented diet, and treated with vehicle or statin.

MALES	Vehicle		Statin		2-way ANOVA
MALES	WT	Scly KO	WT	Scly KO	P_int	P_Statin	P_Gen
GPX act serum (nmol/mL⁻¹)	40.7±1.5	43.0±2.4	41.0±1.0	41.9±1.0	0.342	0.6052	0.0399
GPX act liver (nmol/mg¹)	1.24±0.04	1.20±0.04	1.17±0.03	1.23±0.05	0.0132	0.2036	0.6066
HNE serum (μg/mL)	3.4±1.6	8.5±8.2^*	2.6±1.6	5.0±3.4^*^#	0.4234	0.2151	0.0322
HNE liver (μg/mL)	12.8±5.4^#	18. 9±10.9	6.2±3.5	7.3±4.1^#	0.3531	0.0023	0.1874

FEMALES	Vehicle		Statin		2-way ANOVA
FEMALES	WT	Scly KO	WT	Scly KO	P_int	P_Statin	P_Gen
GPX act serum (nmol/mL⁻¹)	49.4±1.2	52.0±1.0	46.7±0.9	50.9±1.9^*	0.1945	0.0053	<0.0001
GPX act liver (nmol/mg¹)	1.33±0.11	1.25±0.04	1.26±0.07	1.23±0.04	0.3226	0.1726	0.093
HNE serum (μg/mL)	3.9±1.4	7.7±4.4^*	3.4±0.8	5.6±2.2^*^#	0.4948	0.2437	0.0157
HNE liver (μg/mL)	14.5±14.2	31.7±16.7^*	11.1±3.7	9.4±3.6^#	0.0504	0.014	0.1148

Values are mean ± SEM. Two-way analysis of variance (ANOVA) was applied, followed by a Bonferroni post hoc test. Italicized numbers represent P<0.05 after 2-way ANOVA.

^(*)

represents P <0.05 between Scly KO and WT, and

^(#)

represents within the same genotype groups after post hoc test. P-values under 0.05 deemed significant; n = 5–8 per group. WT: wild type, KO: knockout; GPX: glutathione peroxidase, HNE: 4-Hydroxy-Trans-2-Nonenal; Act: activity; Int: interaction; Gen: genotype.