Table 2.
Pathways exhibiting the highest transcript enrichment between vehicle- and statin-treated WT and Scly KO mice unveiled by online Enrichr tool.
| Males - WT and Scly KO (Vehicle × Statin) | |||||
|---|---|---|---|---|---|
| GO Biological Process | |||||
| Term | Overlap | Gene | P-adj | Odds ratio | Combined score |
| regulation of insulin-like growth factor receptor signaling pathway (GO:0043567) | 1/19 | Igfbp2 | 1 | 392.1568 | 2342.1 |
| GO Molecular Function | |||||
| Term | Overlap | Gene | P-adj | Odds ratio | Combined score |
| insulin-like growth factor II binding (GO:0031995) | 1/7 | Igfbp2 | 1 | 952.3810 | 6532.7 |
| Females - WT and Scly KO (Vehicle × Statin) | |||||
| GO Biological Process | |||||
| Term | Overlap | Gene | P-adj | Odds ratio | Combined score |
| negative regulation of glucocorticoid receptor signaling pathway (GO:2000323) | 1/6 | Per1 | 1 | 277.77778 | 1563.3921 |
| GO Molecular Function | |||||
| Term | Overlap | Gene | P-adj | Odds ratio | Combined score |
| phosphorylase activity (GO:0004645) | 1/6 | Tymp | 1 | 277.77778 | 1563.3921 |
WT: wild type, KO: knockout.