Table 2.

Hazard ratios per additional year of age for individual tumour type

	Overall					Female					Male
	Unadjusted			Adjusted*		Unadjusted			Adjusted§		Unadjusted			Adjusted§
Tumour	Median age (range)	HR(95% CI)	P value	HR(95% CI)	P value	Median age (range)	HR(95% CI)	P value	HR(95% CI)	P value	Median age (range)	HR(95% CI)	P value	HR(95% CI)	P value
Anaplastic astrocytoma	10.0 (0–19)	0.99 (0.96–1.01)	0.29	0.98 (0.96–1.01)	0.26	10.0 (0–10)	1.00 (0.96–1.04)	0.91	1.00 (0.96–1.04)	0.97	9.5 (0–19)	0.97 (0.93–1.01)	0.09	0.97 (0.93–1.01)	0.10
Ependymoma	6.0 (0–19)	0.95 (0.93–0.98)	<0.01	0.95 (0.92–0.98)	<0.01	5.0 (0–19)	0.96 (0.91–1.01)	0.07	0.96 (0.91–1.01)	0.08	6.0 (0–19)	0.95 (0.91–0.99)	0.01	0.95 (0.91–0.99)	0.01
Glioblastoma multiforme	11.0 (0–19)	0.99 (0.97–1.02)	0.59	0.99 (0.97–1.01)	0.50	10.0 (0–19)	0.99 (0.95–1.02)	0.41	0.99 (0.95–1.02)	0.43	12.0 (0–19)	1.00 (0.97–1.02)	0.86	0.99 (0.97–1.02)	0.69
Germinoma	13.0 (0–19)	0.94 (0.89–0.99)	0.02	0.95 (0.90–1.00)	0.05	11.0 (0–19)	0.82 (0.75–0.90)	<0.01	0.82 (0.76–0.90)	<0.01	14.0 (0–19)	1.06 (0.98–1.16)	0.17	1.06 (0.97–1.16)	0.17
Medulloblastoma	6.0 (0–19)	0.95 (0.93–0.98)	<0.01	0.95 (0.93–0.97)	<0.01	6.5 (0–19)	0.94 (0.91–0.98)	<001	0.94 (0.91–0.98)	<0.01	6.0 (0–19)	0.96 (0.93–0.99)	<0.01	0.96 (0.93–0.99)	<0.01
Pilocytic astrocytoma	8 (0–19)	0.99 (0.94–1.03)	0.50	0.99 (0.94–1.03)	0.54	8.0 (0–19)	0.93 (0.88–0.99)	0.04	0.93 (0.88–0.99)	0.04	8.0 (0–19)	1.04 (0.98–1.10)	0.23	1.04 (0.98–1.11)	0.22
sPNET	6.0 (0–19)	0.98 (0.95–1.00)	0.06	0.98 (0.95–1.00)	0.07	6.0 (0–19)	0.99 (0.95–1.03)	0.58	0.90 (0.93–1.03)	0.55	6.5 (0–19)	0.93 (0.93–0.99)	0.04	0.96 (0.93–1.00)	0.05

*Adjusted for year of diagnosis and sex genotype

^§adjusted for year of diagnosis

HR hazard ratio, CI confidence intervals