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. 2021 Jul 7;11:14052. doi: 10.1038/s41598-021-93467-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Unsupervised analysis of gene expression profiles in mouse HCC. (a) Unsupervised Principle Component Analysis (PCA) indicated distinct gene expression profiles between HCC and non-HCC liver samples. (b) Sources of Variation (SOV) analysis showed that HCC contributed to the largest variances. Interactions of HCC and radiation showed a slight increase in F ratios, which indicates modest differences in HCC induced by different radiation types.