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. 2021 Jul 7;11:14052. doi: 10.1038/s41598-021-93467-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Profiles of tumor-infiltrating immune cells in mouse and human HCC. (a) Average values of relative proportions of immune cells in each mrHCC cluster of human TCGA HCC cohorts. Bar: standard error. *Immune cell proportions of mrHCC2 were significantly different from either mrHCC1 or mrHCC3 (p < 0.05). (b) Average values of relative proportions of immune cells in high-LET, low-LET and spontaneous mouse HCC. Bar: standard error. (c) Ratios of CD4+/CD8+ tumor-infiltrating T cells in different subgroups of mouse and human HCC. Bar: standard error.