Fig. 3. Aberrant NF-κB pathway activated by somatic gene alterations and EBV latent gene.

A Somatic aberrations activating NF-κB and LMP expression in 70 NPC samples. NPC tumors with LMP1 overexpression are also indicated. B LMP1 overexpression and somatic aberrations activating NF-κB pathway are mutually exclusive at the whole-genome level in NPC (two-sided Fisher’s exact test p = 3.5 × 10⁻⁶, ****P < 0.0001). Boxplot is defined as follows: center upper whisker = min(max(x), Q_3 + 1.5 * IQR), lower whisker = max(min(x), Q_1 – 1.5 * IQR); where IQR = Q_3−Q_1, the bounds of the box. LMP1 expression was examined in NPC tumor specimens (n = 65) by immunohistochemistry staining. IHC staining and scoring were performed twice in the tumors and similar results were observed. Representative images of NPC cases with high (+ve) or absence/low (−ve) LMP1 expression are shown. Scale bar: 10 μm. Source data are provided as a Source Data file.