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. 2021 Jul 7;12:4191. doi: 10.1038/s41467-021-24516-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The age distribution of women and the number of samples in different groups in this study. Gray bars, red bars, hollow bars, and solid bars represent women from previous studies, from this study, with single uterine or vaginal sample types, and with paired uterine-vaginal sample types, respectively. The number of samples in each age group is given on the bar. The number of sequenced samples from the uterus and vagina and information on chronic endometritis, delivery mode, and abortion history are shown in brackets and tables. Red and gray numbers indicate the samples collected in this study and in previous studies, respectively. b Microbial diversities of the uterine and vaginal microbiome in women of different ages. The scales 10+, 20+, 30+, 40 +, 50+, and 60+ on the x-axis represent ages <20, 20–29, 30–39, 40–49, 50–59, and ≥60 years, respectively. The shadow around the linear regression trendline shows the 95% confidence interval (CI). c The Bray-Curtis (BC) distance of the microbial communities among individuals of the same age group. Box-plot elements are defined as: center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers. d The BC distance of the microbial communities among individuals within the same age group and between different age groups. e Principal coordinate analysis (PCoA) of the uterine and vaginal microbiome at each age stage. Each circle shows a 10% CI of each age group, and the arrow connects the vertical center of each circle. f The bacterial abundance of the uterine and vaginal microbiome at the phylum level, with different colors correspond to different phyla.