Fig. 3. Synchronous variations in the uterine and vaginal microbiome and the correlation to clinical factors.
a The age distribution of 1,612 women interviewed from two hospitals. b The average (AVG) number and percentage of pregnancies, deliveries, and abortions in women with and without chronic endometritis. c Bray-Curtis (BC) community distance of the paired uterine and vaginal samples with age. The scales 10+, 20+, 30+, 40+, 50+, and 60+ on the x-axis represent ages <20, 20–29, 30–39, 40–49, 50–59, and ≥60, respectively. d BC distance of uterine-vaginal paired samples associated with abortion history. The distance was calculated at the OTU level in the microbiome of women with and without chronic endometritis. e BC community distance of uterine-vaginal paired samples associated with the previous delivery mode. f The relative abundance of three bacterial genera in the uterine (red) and vaginal (blue) microbiome with age. The values were normalized to 105 reads in each sample. g Relative abundance of three bacterial genera along with the number of abortions. h Relative abundance of three bacterial genera along with the previous delivery mode. For c–e and h, box and violin elements are defined as: center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers; the width of the violin represents the density distribution. P values were determined by two-tailed Wilcoxon test. For f, g the shadow around the linear regression trendline shows the 95% confidence interval (CI).