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. 2021 Jul 7;11:14004. doi: 10.1038/s41598-021-93401-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of metabolite changes resulting from exposure to ⁶⁰Co γ-radiation. (A) Venn diagram summarizing dysregulated metabolites from the three cohorts and raindrop plot illustrations of radiation effects in cohorts 1 to 3. (B) Venn diagram summarizing the metabolic pathways from cohort 3 that were dysregulated with or without amifostine treatment (200 mg/kg) and raindrop plot illustrations of shared metabolites between RAD D1vD5 and RAD+200 D5vD9. Raindrop plot illustration show model changes by fold change (logFC) and p-value (− log10 PV).