Table 1.
Summary of patient and tumor characteristics overall and by ATF4 copy number
| Variable | N | Overall | ATF4 gene copy number | p-value | ||
|---|---|---|---|---|---|---|
|
| ||||||
| 0 copy (0N) (n=3) | 1 copy (1N) (n=21) | 2 copies (2N) (n=35) | ||||
| Age, median (range), years | 59 | 52 (23-73) | 38 (34-40) | 54 (28-73) | 52 (23-72) | 0.199 |
| Sex, N (%) | 59 | 0.414 | ||||
| Female | 33 (56) | 1 (33) | 10 (48) | 22 (63) | ||
| Male | 26 (44) | 2 (67) | 11 (52) | 13 (37) | ||
| RET M918T mutation, N (%) | 57 | 0.811 | ||||
| Positive | 23 (40) | 1 (33) | 10 (48) | 12 (36) | ||
| Negative | 34 (60) | 2 (67) | 11 (52) | 21 (64) | ||
| pT category, N (%) | 57 | 0.599 | ||||
| T1 | 13 (23) | 0 (0) | 3 (15) | 10 (29) | ||
| T2 | 12 (21) | 0 (0) | 4 (20) | 8 (24) | ||
| T3 | 16 (28) | 1 (33) | 6 (30) | 9 (26) | ||
| T4a | 16 (28) | 2 (67) | 7 (35) | 7 (21) | ||
| pN category, N (%) | 57 | 0.853 | ||||
| N0 | 13 (23) | 0 (0) | 4 (19) | 9 (27) | ||
| N1/N1a | 9 (16) | 0 (0) | 4 (19) | 5 (15) | ||
| N1b | 35 (61) | 3 (100) | 13 (62) | 19 (58) | ||
| M category, N (%) | 59 | 0.742 | ||||
| M0 | 35 (59) | 1 (33) | 13 (62) | 21 (60) | ||
| M1 | 24 (41) | 2 (67) | 8 (38) | 14 (40) | ||
| Extrathyroidal invasion, N (%) | 45 | 0.258 | ||||
| No | 27 (60) | 2 (67) | 6 (43) | 19 (68) | ||
| Yes | 18 (40) | 1 (33) | 8 (57) | 9 (32) | ||
| Distant metastases, N (%) | 52 | 0.466 | ||||
| No | 28 (54) | 1 (33) | 8 (44) | 19 (61) | ||
| Yes | 24 (46) | 2 (67) | 10 (56) | 12 (39) | ||
| Stage, N (%)^ | 59 | 0.571 | ||||
| I | 5 (8) | 1 (33) | 0 (0) | 4 (11) | ||
| II | 4 (7) | 0 (0) | 1 (5) | 3 (9) | ||
| III | 5 (8) | 0 (0) | 2 (10) | 3 (9) | ||
| IVa | 16 (27) | 0 (0) | 6 (29) | 10 (29) | ||
| IVc | 29 (49) | 2 (67) | 12 (57) | 15 (43) | ||
N = total number per variable;
^
AJCC 7th edition.