Table 3.
Univariable and multivariable Cox analysis of overall survival by clinical and tumor characteristics
| Prognostic Factor | N | Events | HR | 95% CI | p-value |
|---|---|---|---|---|---|
| Age | |||||
| ≤52 (ref) | 30 | 10 | - | - | - |
| >52 | 29 | 10 | 1.39 | (0.56, 3.47) | 0.478 |
| Sex | |||||
| Female (ref) | 33 | 9 | - | - | - |
| Male | 26 | 11 | 0.93 | (0.35, 2.44) | 0.883 |
| ATF4 protein | |||||
| High (ref) | 26 | 3 | - | - | - |
| Low | 33 | 17 | 6.21 | (1.81, 21.28) | 0.004 |
| ATF4 copy number | |||||
| 2N (ref) | 35 | 6 | - | - | - |
| Loss, 0N/1N | 24 | 14 | 3.26 | (1.25, 8.54) | 0.016 |
| RET M918T mutation | |||||
| Negative (ref) | 34 | 9 | - | - | - |
| Positive | 23 | 11 | 1.49 | (0.62, 3.61) | 0.376 |
| pT category | |||||
| T1 (ref) | 13 | 2 | - | - | - |
| T2 | 12 | 2 | 0.57 | (0.08, 4.14) | 0.581 |
| T3 | 16 | 5 | 1.51 | (0.29, 7.92) | 0.626 |
| T4a | 16 | 10 | 2.54 | (0.53, 12.08) | 0.242 |
| pN category | |||||
| N0 (ref) | 13 | 0 | - | - | - |
| N1 | 44 | 20 | 11.52 | (1.57, 1467.52) | 0.009 |
| M category | |||||
| M0 (ref) | 35 | 8 | - | - | - |
| M1 | 24 | 12 | 1.50 | (0.59, 3.84) | 0.395 |
| Extrathyroidal invasion | |||||
| No (ref) | 27 | 6 | - | - | - |
| Yes | 18 | 6 | 1.26 | (0.40, 3.96) | 0.692 |
| Stage^ | |||||
| I (ref) | 5 | 2 | - | - | - |
| II | 4 | 0 | 0.12 | (0.00, 1.49) | 0.103 |
| III | 5 | 1 | 0.57 | (0.05, 4.31) | 0.578 |
| IVa | 16 | 4 | 0.24 | (0.05, 1.51) | 0.120 |
| IVc | 29 | 13 | 0.56 | (0.16, 2.91) | 0.437 |
| ATF4 protein/RET mutation status* | |||||
| High/negative (ref) | 14 | 1 | - | - | - |
| High/M918T | 11 | 2 | 2.97 | (0.26, 33.17) | 0.378 |
| Low/negative | 20 | 8 | 10.64 | (1.30, 87.10) | 0.027 |
| Low/M918T | 12 | 9 | 11.66 | (1.47, 92.29) | 0.020 |
| ATF4 copy number/RET mutation status* | |||||
| 2N/negative (ref) | 21 | 3 | - | - | - |
| 2N/M918T | 12 | 3 | 1.68 | (0.33, 8.47) | 0.528 |
| 0N or 1N/negative | 13 | 6 | 3.79 | (0.93, 15.45) | 0.063 |
| 0N or 1N/M918T | 11 | 8 | 4.06 | (1.07, 15.41) | 0.040 |
0N: homozygous deletion, 1N: one copy, 2N: diploid, Low: <20% expression, High: >20% expression, HR: hazard ratio, M918T: RETM918T present, negative: absent RETM918T mutation, Ref: reference;
^
AJCC 7th edition;
*
RET mutation status specifically for M918T.