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NONO promotes the EGFR-induced DNAPK activation by enhancing their interaction. (A) EGFR inhibitor AG1478 treatment inhibited IR-induced phosphorylation of DNAPK at T2609. (B) NONO depletion inhibited radiation-induced DNA-PK phosphorylation. (C) NONO knockout suppressed the radiation-induced association of EGFR and DNA-PK. For (A-C), the cytoplasmic and nuclear proteins were fractionated from U2OS cells.
