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Model of NONO condensates promote DNA repair and radioresistance via acceleration of EGFR-mediated DNA-PK activation. During the irradiation-induced DDR, NONO condensates recruit DNA-PK and nEGFR, which is activated and translocated into nucleus, to enhance the interaction between EGFR and DNA-PK, thereby increases the autophosphorylation of DNA-PK at T2609, promotes NHEJ-mediated DNA repair and induces tumor radioresistance.
