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. 2021 Jun 15;11(6):2537–2567.

Figure 7.

Figure 7

ASPH activates SRC signaling pathway. A. Expression profiling of ADAM12/ADAM15 in breast cancer cell lines. B. Direct physical interaction of endogenous ASPH with endogenous ADAM12 or ADAM15 in T47D cells. C. A direct physical interaction of ASPH with ADAM12 or ADAM15 was detected by co-IP in HEK293 cells. D. ASPH or ADAM12 overexpression activated SRC. E. ADAM12/ADAM15 induced SRC activation was blocked by Dasatinib (BCR-ABL/SRC family tyrosine kinase inhibitor) in MDA-MB-231 cells. F-H. ASPH significantly enhanced activation of SRC signaling, which was reversed by the SMI and SRC inhibitor Dasatinib. I-L. ECM degradation in response to Dasatinib. *P < 0.05; **P < 0.01; ***P < 0.001.