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. 2021 Jun 15;11(6):2537–2567.

Figure 13.

Figure 13

ASPH activates SRC signaling in breast cancer patients. A, B. Expression pattern of ASPH-ADAM12-SRC axis in breast cancer patients. Inactivation vs. activation of SRC (phosphorylated at Tyr416) and consistent downregulation vs. upregulation of ADAM12 or MMPs in ASPH negative vs. ASPH positive tumor cells. C-E. Expression profile of ASPH, activated SRC (phosphorylated at Tyr416/418), ADAM12 and MMPs in tumor cells compared to adjacent non-malignant tissues of breast cancer patients (P < 0.001, 2-sided paired t test). ADAM12-SRC-MMPs pathway was consistently upregulated/activated or downregulated/inactivated in ASPH positive vs. negative breast cancer patients. F-J. ASPH positively correlated with active SRC, ADAM12, MMPs; ADAM12 positively correlated with active SRC expression in breast cancer patients. *P < 0.05; **P < 0.01; ***P < 0.001.