Table 3.
Univariate analysis of MVI presence based on preoperative data in HCC patients.
| Variables | Without MVI (n = 125) | MVI (n = 117) | T/χ2 | P value |
|---|---|---|---|---|
| Age | 60.4 ± 10.5 | 59.7 ± 10.4 | 0.13 | 0.719 |
| Gender | ||||
| Male | 106 (84.8) | 91 (77.8) | 1.97 | 0.161 |
| Female | 19 (15.2) | 26 (22.2) | ||
| HBeAg | ||||
| Positive | 103 (82.4) | 89 (76.1) | 1.48 | 0.224 |
| Negative | 22 (17.6) | 28 (23.9) | ||
| HBV DNA (IU/mL) | ||||
| Non-HBV | 22 (17.6) | 28 (23.9) | 2.55 | 0.279 |
| ≤ 103 | 74 (56.8) | 55 (47.0) | ||
| 103–105 | 32 (25.6) | 34 (29.1) | ||
| Anti-HBV therapy | ||||
| No | 66 (52.8) | 71 (60.7) | ||
| Yes | 59 (47.2) | 46 (39.3) | ||
| Family history of HCC | ||||
| No | 119 (95.2) | 112 (95.7) | 0.04 | 0.844 |
| Yes | 5 (4.8) | 5 (4.3) | ||
| Hypertension | ||||
| No | 98 (78.4) | 82 (70.1) | 2.19 | 0.139 |
| Yes | 27 (21.6) | 35 (29.9) | ||
| Diabetes | ||||
| No | 109 (87.2) | 101 (86.3) | 0.04 | 0.841 |
| Yes | 16 (12.8) | 16 (13.7) | ||
| Hypertension with diabetes | ||||
| No | 117 (93.6) | 110 (94.0) | 0.02 | 0.893 |
| Yes | 8 (6.4) | 7 (6.0) | ||
| ALT (U/L) | ||||
| ≤ 50 | 94 (75.2) | 84 (71.8) | 0.36 | 0.548 |
| > 50 | 31 (24.8) | 33 (28.2) | ||
| AST (U/L) | ||||
| ≤ 40 | 86 (68.8) | 62 (53.0) | 6.36 | 0.012 |
| > 40 | 39 (31.2) | 55 (47.0) | ||
| GGT (U/L) | ||||
| ≤ 60 | 76 (60.8) | 53 (45.3) | 5.83 | 0.016 |
| > 60 | 49 (39.2) | 64 (54.7) | ||
| Platelets (× 109/L) | ||||
| ≤ 125 | 35 (28.0) | 37 (31.6) | 0.38 | 0.538 |
| > 125 | 90 (72.0) | 80 (68.4) | ||
| TT (seconds) | ||||
| ≤ 16.6 s | 89 (71.2) | 92 (78.6) | 1.77 | 0.183 |
| > 16.6 s | 36 (28.8) | 25 (21.4) | ||
| PT (seconds) | ||||
| ≤ 13.1 s | 100 (80.0) | 93 (79.5) | 0.01 | 0.921 |
| > 13.1 s | 25 (20.0) | 24 (20.5) | ||
| TB (umol/l) | ||||
| ≤ 23 | 111 (88.8) | 95 (81.2) | 2.76 | 0.097 |
| > 23 | 14 (11.2) | 22 (18.8) | ||
| DB (umol/l) | ||||
| ≤ 8 | 106 (84.8) | 92 (78.6) | 1.54 | 0.214 |
| > 8 | 19 (15.2) | 25 (21.4) | ||
| AFP (ng/mL) | ||||
| ≤ 20 | 69 (55.2) | 38 (32.5) | 16.08 | < 0.001 |
| 20–400 | 34 (27.2) | 35 (29.9) | ||
| > 400 | 22 (17.6) | 44 (37.6) | ||
| Imaging results | ||||
| Tumor diameter (cm) | 4.12 ± 2.24 | 5.75 ± 2.91 | 12.42 | 0.001 |
| No. of tumors | ||||
| Solitary | 94 (75.2) | 88 (75.2) | < 0.001 | 0.998 |
| Multiple | 31 (24.8) | 29 (24.8) | ||
| Cirrhosis | ||||
| No | 79 (63.2) | 75 (64.1) | 0.02 | 0.884 |
| Yes | 46 (36.8) | 42 (35.9) | ||
MVI microvascular invasion, HbeAg hepatitis B e antigen, HBV hepatitis B virus, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyl transpeptidase, TT thrombin time, PT prothrombin time, TB total bilirubin; DB direct bilirubin, AFP α-fetoprotein.