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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Jan 8;83:100941. doi: 10.1016/j.preteyeres.2021.100941

Figure 3. Unrooted phylogenetic tree for mammalian UCPs, plant uncoupling proteins (PUMPs) and other mitochondrial carrier protein sequences.

Figure 3.

The lengths of the lines connecting genes corresponds to the relative evolutionary distance (sequence divergence) between them. The clusters (shaded) represent groups of genes that are much more closely related to each other than to any others on the tree. UCP1, UCP2 and UCP3 appear in cluster I, UCP4 in cluster III and UCP5 in cluster IV. Figure reproduced from (Nogueira et al., 2005) with permission. The tree indicates an early separation of UCP4 and 5, a second separation on non-vertebrate uncoupling proteins and then the later separation into the UCP1,2, and 3 forms of uncoupling protein. The following sequences (accession numbers in parentheses) were used for the phylogenetic analysis: UCP1_MOUSE (P12242), UCP1_RAT (P04633), UCP1_RABBIT (P14271), UCP1_HUMAN (P25874), UCP2_HUMAN (P55851), UCP2_CANFA (Q9N2J1), UCP2_RAT (P56500), PsUCP2 (AAG33984), UCP2_MOUSE (P70406), UCP2_PIG (097562), X1UCPput (AAH44682), UCP2_BRARE (Q9W720), UCP2_CYPCA (Q9W725), UCP3_MOUSE (P56501), UCP3_RAT (P56499), PsUCP3 (AAG33985), UCP3_CANFA (Q9N2I9), UCP3_PIG (097649), UCP3_HUMAN (P55916), UCP3_BOVIN (077792), UCP-gallus (AAL35325.2), MgUCP (AAL28138), EmUCP (AAK16829), PmUCP2 (AAL92117), GmPUMPlb (AAL68563), GmPUMPla (AAL68562), MiPUMP-1 (AAK70939), LePUMP (AAL82482), AtPVMP1 (CAA11757), SfUCP (BAA92172), HmUCP (BAC06495), ZmPUMP (AAL87666), OsPUMP1 (BAB40657), OsPUMP2 (BAB40658), OsPUMP3 (CAE01569), OsPUMP4 (BAD09745), TaPUMP1 (BAB16385), AtPUMP2 (NP_568894), AtPUMP3 (F7A19_22), AtPUMP4 (F22K18_230), AtPUMP5 (F14M13_10), AtPUMP6 (T5E8_270), DIC_MOUSE (Q9QZD8), RnDCput (NP_596909), DIC_HUMAN (Q9UBX3), CeM2OM (NP_509133), NcDCput (XP_327953), M2OM_MOUSE (Q9CR62), M2OM_RAT (P97700), M2OM_HUMAN (Q02978), M2OM_BOVIN (P22292), NtDTC (CAC84545), StM2OM (CAA68164), AtM2OM (NP_197477), PmM2OM2 (S65042), P1aFa1M2OM (CAD51134), P1aYoeM2OM (EAA21506), BMCP1/UCP5 MOUSE (Q9Z2B2), MmBMCP1/UCP5 (NP_035528), RnBMCP1/UCP5 (NP_445953), BMCP1/UCP5_HUMAN (095258), UCP4_HUMAN (095847), MmUCP4 (BAC66453), RnUCP4a (CAC20898), RnUCP4b (CAC20899), RnUCP4c (CAC20900), and CeUCP (NP_505414). Protein abbreviations are from the SWISPROT database.