Table 2.
Follow-up cohorts.
| Cohort | Type | DNA methylation | Phenotype | N | % female | Mean age (SD) | Aggression mean (SD) |
|---|---|---|---|---|---|---|---|
| NeuroIMAGE [41] | Clinical cohort; ADHD | Illumina EPIC | Callous Traits | 71 | 28.2 | 21 (2.9) | 9.3 (4.4) |
| FemNAT-CD [42] | Clinical cohort; Conduct disorder | HpaII methylation Sequencing | Case-control status | Total: 100 Cases: 50 Controls: 50 | 100 | Cases: 16.1(1.6) Controls: 15.8(1.5) | NA |
| ACTION –NTR [43] | Twin cohort, selected on aggression (high-low) | Illumina EPIC | CBCL aggression | 1237 | 47.4 | 9.6 (1.9) | 5.0 (5.4) |
| ACTION-Curium-LUMC [43] | Clinical cohort; children with severe and complex mental health problems | Illumina EPIC | CBCL aggression | 172 | 25.6 | 9.6 (1.7) | 13.1 (7.6) |
NeuroIMAGE The NeuroIMAGE study is a follow-up of the Dutch part of the International Multicenter ADHD Genetics (IMAGE) project, FemNAT-CD Neurobiology and Treatment of Adolescent Female Conduct Disorder, ACTION Aggression in children: unraveling gene-environment interplay to inform Treatment and InterventiON strategies, NTR Netherlands Twin Register.