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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Jan 8;84:100940. doi: 10.1016/j.preteyeres.2021.100940

Figure 5. AlphaA-crystallin chaperone protein while increasingly expressed is decreasingly phosphorylated on a key regulatory site in DR donors.

Figure 5.

AlphaA-crystallin total protein level was assessed by western-blot and showed to be increased in diabetic donors with or without DR (left). Concomitantly, phosphorylation on T148, a phosphosite controlling its protective function was assessed by multiple reaction monitoring and shown to be dramatically reduced in DR donors. (Adapted from Ruebsam et al., 2018)