Skip to main content
. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Jan 8;84:100940. doi: 10.1016/j.preteyeres.2021.100940

Table 2. Top ten pathways affected by diabetes and reversed by ocular insulin administration.

List of the top ten pathways obtained considering only the list of genes from the microarray analysis that were affected by diabetes and reversed by local insulin administration using MetaCore™ (Genego Inc.) software. Pathways are ranked based upon p-value (Adapted from Fort et al., 2011).

ranking Maps min(pValue)
1 Immune response_Classical complement pathway 4.112E-12
2 Cell adhesion_Role of tetraspanins in the integrin-mediated cell adhesion 5.144E-09
3 Immune response_Lectin induced complement pathway 9.611E-08
4 Regulation of lipid metabolism_Regulation of lipid metabolism via LXR, NF-Y and SREBP 1.089E-07
5 Development_Role of IL-8 in angiogenesis 5.124E-07
6 Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases 8.567E-06
7 Immune response_IL-22 signaling pathway 7.801E-05
8 Cytoskeleton remodeling_Neurofilaments 1.972E-04
9 Immune response_IL-5 signalling 4.053E-04
10 Development_Slit-Robo signaling 4.831E-04