Figure 7.

A 23-year-old male patient presented with abdominal pain and was later diagnosed with MEN2B. (A,B) Inspection showed multiple eyelid masses (circle) and tongue mucosal tumor-like hyperplasia (arrows). The lesions were pathologically confirmed as neuromas of the eyelids and mucosal neuromas of the tongue. (C,D) Ultrasound images showed thyroid lesions with mixed echoes, calcification, unclear boundaries, and abundant blood supply. (E) Coronal reconstruction image showed multiple high-density nodules on the thoracic vertebrae. They were pathologically confirmed as bone metastases of MTC. (F) Contrast-enhanced CT image showed a significantly enhanced round-like nodule (arrow) in the left adrenal junction, which was pathologically confirmed as adrenal pheochromocytomas. (G) The nodule (arrow) in the left adrenal junction was positive on a somatostatin receptor image. (H) Axial contrast-enhanced CT image showed that the small intestine wall was thickened and uniformly strengthened in segments (arrows). The lesions were pathologically confirmed as multiple submucosal gangliomas of the intestine. The RET gene mutation was detected in the genetic examination. MEN2B, multiple endocrine neoplasia type 2B; MTC, medullary thyroid carcinoma; CT, computed tomography; RET, rearranged during transfection proto-oncogene.