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. 2021 Jun 24;13:650930. doi: 10.3389/fnagi.2021.650930

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Copyright © 2021 Ali, Khan, Alam, Ahmad, Ikram, Park, Lee and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram. (A) These schematic illustrations show our hypothesis for interaction and synergistic effects of an environmental factor (Cd) and aging. (B) The illustrative graphical representation indicated our study designing to establish the control of aging and Cd-induced aging models. The treatment paradigms, behavioral studies [Morris water maze (MWM) and Y-maze tests], animal authorization, and biochemical as well as immunohistochemical representation were indicated for the entire study.