FIGURE 9.

Analysis of differentially expressed proteins derived from TSA‐EVs and MO‐EVs. a) Volcano plot displaying Log₂ values for the proteins fold‐change against Log₁₀ FDR. Proteins with a Log₂ fold difference below 1 and a statistical value of > 0.05 were not considered to be statistically significant (vertical and horizontal lines respectively). The red points in the plot represents the significantly upregulated TSA‐EV proteins, the green points represent significantly upregulated MO‐EVs proteins. b) Venn diagram comparing proteins differentially expressed from TSA‐EVs and MO‐EVs. A total of 1273 shared proteins; 25 proteins upregulated in TSA‐EVs and 27 proteins upregulated in MO‐EVs. c) Pearson correlations between technical replicates, biological replicates and sample groups were determined. GO analysis of proteins found to be significantly upregulated in TSA‐EVs. Top ten GO prediction scores covering the domains of d) molecular function, e) cellular components and f) biological processes of proteins significantly upregulated in TSA‐EVs