Table 4.
The mutational frequency of epigenetic related gene in CTCL (according to Park J et al. genomic analysis of 220 CTCLs).
| Epigenetic Genes | Function | alteration | Frequency |
|---|---|---|---|
| DNMT3A | DNA Methylation | deletion and mutation | 4% deletion and 38% mutation |
| ARID1A, | Nucleosome remodeler | deletion and mutation | 5% deletions and 58% mutation |
| CREBBP | Histone acetylation | mutation | 6% |
| SETD2B | Histone methylation | mutation | 28% |
| TET2 | DNA demethylation | mutation | 6% |
| NCOR1 | Histone deacetylation | deletion and mutation | 3.1 and 80% |