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. 2021 Jul 6;153(9):e202012832. doi: 10.1085/jgp.202012832

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© 2021 Zhao et al.

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Figure 4. — Impact of phenyl ring fluorination on ABI-mediated inhibition of Hv1 WT and F150A. (A) Structures of tested ABIs showing positions of fluoro substituents in condensed phenyl ring (yellow shade). (B–E) Concentration-dependences of inhibition of Hv1 WT (B and C) and F150A (D and E) by the indicated compounds. Each data point is the average value from three to eight independent measurements. Error bars are SD. Curved lines represent fits of the data using Eq. 1. See Table S1 for fit parameters. Dotted line in B indicates extrapolation of the IC for ABIF₃ to concentrations >1 mM (the compound was not soluble at higher concentrations under tested conditions).