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. 2021 Jun 24;12:650884. doi: 10.3389/fneur.2021.650884

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Copyright © 2021 Hwang, Park, Park, Lee, Oh and Suh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of long-term normalized signal intensities (SIs) in the scala vestibuli (SV) and scala tympani (ST) after intratympanic (IT) gadolinium (Gd) injection with two different vehicles. The SI was higher when Gd-DO3A-butrol was delivered in a high-molecular-weight (hMW) hyaluronic acid (HA) vehicle instead of saline. This difference was most significant at 1 h after IT Gd injection in the basal and middle turns. The significant elevation in SI lasted for 7–10 days after hMW HA+Gd injection in the basal (SV and ST) and apical (ST) turns. *p < 0.05.