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. 2021 Jun 24;11:704722. doi: 10.3389/fonc.2021.704722

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Copyright © 2021 Badros, Meddeb, Weikel, Philip, Milliron, Lapidus, Hester, Goloubeva, Meiller and Mongodin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Comparison of Alpha Diversity Metrics Between BRONJ and Control. Violin plots comparing the alpha-diversity metrics for richness (Observed and Chao1) and diversity (Shannon) between control (red) and BRONJ (blue). The graphs show significantly lower richness and diversity in BRONJ patients. The significance of difference was calculated using Kruskal-Wallis test with Conferroni correction. (B) Comparison of Alpha Diversity (Chao1 Richness) Between BRONJ and Control across study time points. (C) Principal coordinate analysis (PCoA) of oral cavity microbiota using Bray–Curtis dissimilarity matrix (top) and Jensen Shannon Divergence (bottom). Two-dimensional PCoA was used to describe the relative abundance of oral microbiota. Each point represents a single sample and is colored red for controls and blue for BRONJ.