Table 1.
Demographics and characteristics of the study population.
| Overall | No BRONJ | Developed BRONJ | |
|---|---|---|---|
| N = 110 (100%) | N = 96 (88%) | N = 14 (12%) | |
| At Study Entry | |||
| Age (range, years) | 57 (33–81) | 57 (45–78) | 60 (33–81) |
| Males | 68 (62) | 59 (61) | 9 (64) |
| Race | |||
| ○ Caucasians | 58 (53) | 51 (53) | 7 (50) |
| ○ Blacks | 49 (45) | 43 (45) | 6 (43) |
| ○ Others | 3 (2) | 2 (2) | 1 (1) |
| MM Dx to study, median (range) | |||
| ○ High risk (n = 100) | 3.7 (2.5–13) | ||
| ○ Newly Dx (n = 10) | 0.6 (0.1–0.8) | ||
| MM Dx to BRONJ, median (range) | 5.7 (1.9–12) | ||
| Isotype | |||
| ○ IgG, IgA, Free Light chain | 62, 29, 19 | 56, 25, 14 | 6, 4, 4 |
| Prior SCT | 104 | 94 | 10 |
| MM Response at study entry | |||
| ○ CR | 35 | 31 | 5 |
| ○ PR | 52 | 48 | 4 |
| ○ PD | 23 | 18 | 5 |
| MM Therapy at study entry | |||
| ○ Lenalidomide | 59 | 53 | 6 |
| ○ Carfilzomib | 16 | 11 | 5 |
| ○ Other | 11 | 8 | 4 |
| ○ No therapy | 24 | 24 | – |
| Medical History | |||
| ○ Diabetes mellitus | 25 | 21 | 4 |
| ○ Smoking; continued smoking | 32; 6 | 27; 2 | 5; 4 |
| Dental History | |||
| ○ Followed dental care | 66 | 54 | 9 |
| ○ Periodontal Disease | |||
| - Mild | 45 | 39 | 6 |
| - Severe | 47 | 44 | 3 |
| ○ Decay and Fracture | 15 | 15 | – |
| ○ Using Dentures | 15 | 14 | 1 |
| While On Study | |||
| Zoledronic acid infusions | |||
| ○ 1 Month | 75 | 66 | 9 |
| ○ 3 Months | 35 | 30 | 5 |
| MM Relapse | 50 | 42 | 8 |
| Dental Extractions | 10 | 5 | 5 |
| ○ Healed (8 weeks) | 8 | 5 | 3 |
| ○ Did not heal | 2 | 2 | |
BRONJ, bisphosphonate related osteonecrosis of the jaw; MM, multiple myeloma; Dx, diagnosis; CR, complete response; PR, partial response; PD, progressive disease.